HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chlorotrimethylsilane → 2-(3-Methylphenyl)ethan-1-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chlorotrimethylsilane | HCID 6397 | — |
| Reactant | Lithium borohydride | HCID 4148881 | — |
| Reactant | HCID 12623346 | HCID 12623346 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 2-(3-Methylphenyl)ethan-1-amine | HCID 410085 | 200.9% |
Reaction Steps
(E)-1-Methyl-3-(2-nitrovinyl)benzene (9 g, 55.214 mmol) was reacted with LiBH4 (4.81 g, 2220.85 mmol), trimethylsilyl chloride (55.86 mL, 441.7 mmol) and dry THF (120 mL) to afford 15 g of the crude product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08946260B2 |
| Source dataset | uspto-grants-2015_02 |
| ORD ID | ord-10e4b7668fe9409084aa6c57da1061ab |
| Source note | uspto-grants-2015_02 |