Potassium Phosphate, Tribasic → HCID 89964570, compound

Participants

Reaction Steps

3-Methyl-7-(trifluoromethyl)-3,4-dihydroisoquinolin-1(2H)-one (I-43d: 60 mg, 0.26 mmol) was reacted with 3-bromo-4-(trifluoromethyl)-pyridine (88 mg, 0.39 mmol), 1,4-dioxane (5 mL), copper iodide (14 mg, 0.078 mmol), trans-N,N′-dimethyl-cyclohexyl-1,2-diamine (3.7 mg, 0.026 mmol) and potassium phosphate (166 mg, 1.78 mmol) to afford the crude product. Purification by column chromatography on silica gel (1.5% methanol in CHCl3), followed by preparative HPLC afforded 3.8 mg of the product (3.8% yield).

Provenance & Evidence