Acetic Anhydride → HCID 89964206, compound

Participants

Reaction Steps

7-Amino-6-methyl-2-(4-(trifluoromethyl)pyridin-3-yl)-3,4-dihydroisoquinolin-1(2H)-one (I-72b: 300 mg, 1.11 mmol) in chloroform (10 mL) was reacted with potassium acetate (153 mg, 1.56 mmol), acetic anhydride (0.213 mL, 2.23 mmol), 18-crown-6-ether (59 mg, 0.223 mmol) and isoamylnitrite (0.33 mL, 2.46 mmol) for 24 hours to afford the crude product. Purification by column chromatography on silica gel (100% ethyl acetate) afforded 80 mg of the product (16.7% yield).

Provenance & Evidence