HuagongsheHuagongshe Chemistry Print Report · For research reference only
Malonic Acid → 3-(3-Fluorophenyl)-2-propenoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Malonic Acid | HCID 867 | — |
| Reactant | Piperidine | HCID 8082 | — |
| Reactant | 3-Fluorobenzaldehyde | HCID 68009 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | 3-(3-Fluorophenyl)-2-propenoic acid | HCID 88606 | 98.6% |
Reaction Steps
3-Fluorobenzaldehyde (5 g, 40.28 mmol) in pyridine (50 mL) was reacted with malonic acid (5.4 g, 52.3 mmol) and piperidine (343 mg, 4.0 mmol) at 75° C. for 12 hours to afford 6.6 g (96.9%) of the crude product which was used in the next step without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08946260B2 |
| Source dataset | uspto-grants-2015_02 |
| ORD ID | ord-de2d629f75cb4adfa9a8ac5f926313b4 |
| Source note | uspto-grants-2015_02 |