HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(3-Fluorophenyl)propionic acid → 5-Fluoro-1-indanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(3-Fluorophenyl)propionic acid | HCID 2737489 | — |
| Solvent | Chlorosulfonic acid | HCID 24638 | — |
| Product | 5-Fluoro-1-indanone | HCID 136537 | 70.5% |
Reaction Steps
3-(3-Fluorophenyl)propanoic acid (I-78b: 2.0 gm, 11.8 mmol) was cyclized with chlorosulfonic acid (20 mL) to afford the crude product. Purification by column chromatography on silica gel (10% ethyl acetate in hexane), afforded 1.2 g of the product (70.5% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08946260B2 |
| Source dataset | uspto-grants-2015_02 |
| ORD ID | ord-2664b470a44b4859aa852740ccf35d7b |
| Source note | uspto-grants-2015_02 |