HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Azide → 6-Fluoro-1,2,3,4-tetrahydroisoquinolin-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Azide | HCID 33557 | — |
| Reactant | 5-Fluoro-1-indanone | HCID 136537 | — |
| Solvent | Trifluoroacetic acid | HCID 6422 | — |
| Product | 6-Fluoro-1,2,3,4-tetrahydroisoquinolin-1-one | HCID 10725709 | 46.2% |
Reaction Steps
5-Fluoro-2,3-dihydro-1H-inden-1-one (I-78c: 1.2 g, 8.0 mmol) in TFA (20 mL) was reacted with sodium azide (1.7 g, 26.4 mmol) to afforded 550 mg of the product (46.2% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08946260B2 |
| Source dataset | uspto-grants-2015_02 |
| ORD ID | ord-448d795e80c2424faa4636be127c7558 |
| Source note | uspto-grants-2015_02 |