Potassium Phosphate, Tribasic → HCID 66807323, compound

Participants

Reaction Steps

6-Fluoro-3,4-dihydroisoquinolin-1(2H)-one (I-78d: 500 mg, 3.029 mmol) was reacted with 3-bromo-4-(trifluoromethyl)-pyridine (890 mg, 3.93 mmol), 1,4-dioxane (15 mL), copper iodide (57.5 mg, 0.30 mmol), trans-N,N′-dimethyl-cyclohexyl-1,2-diamine (43 mg, 0.302 mmol) and potassium phosphate (1.92 g, 9.08 mmol) for 36 hours at 120° C. to afford the crude product. Purification by column chromatography on silica gel (2% methanol in CHCl3), afforded 600 mg of the product (64.5% yield).

Provenance & Evidence