Acetic Acid → HCID 66803632, compound

Participants

Reaction Conditions

Reaction Steps

Iron powder (431.4 mg, 7.72) and acetic acid (10 mL) were added to a stirred solution of 6-fluoro-7-nitro-2-(4-(trifluoromethyl)pyridin-3-yl)-3,4-dihydroisoquinolin-1(2H)-one (I-79a: 550 mg, 1.54 mmol) in THF (5 mL). The resulting mixture was stirred for 4 hours at 70° C. The reaction was monitored by TLC (30% ethyl acetate in hexane). The catalyst was filtered through celite bed and the solvent concentrated under reduced pressure to afford 400 mg of the product (80% yield).

Provenance & Evidence