Potassium Phosphate, Tribasic → HCID 66802250, compound

Participants

Reaction Steps

6-Fluoro-3,4-dihydroisoquinolin-1(2H)-one (I-78d: 500 mg, 3.02938 mmol) was reacted with 3-iodo-4-cyclopropyl-pyridine 816 mg, 3.3323 mmol), 1,4-dioxane (10 mL), copper iodide (57.3 mg, 0.3 mmol), trans-N,N′-dimethyl-cyclohexyl-1,2-diamine (43 mg, 0.30 mmol) and potassium phosphate (1.92 g, 9.0 mmol) to afford the crude product. Purification by column chromatography on silica gel (2% methanol in CHCl3) afforded 700 mg of the product (81.9% yield).

Provenance & Evidence