Sulfuric Acid → HCID 68094409, compound

HRID 1844054Notes

Reaction equation

HRID 1844054 reaction equation
[CH:1]1([C:4]2[CH:9]=[CH:8][N:7]=[CH:6][C:5]=2[N:10]2[CH2:19][CH2:18][C:17]3[C:12](=[CH:13][CH:14]=[C:15]([F:20])[CH:16]=3)[C:11]2=[O:21])[CH2:3][CH2:2]1.OS(O)(=O)=O.[N+:27]([O-])([O-:29])=[O:28].[K+]>>[CH:1]1([C:4]2[CH:9]=[CH:8][N:7]=[CH:6][C:5]=2[N:10]2[CH2:19][CH2:18][C:17]3[C:12](=[CH:13][C:14]([N+:27]([O-:29])=[O:28])=[C:15]([F:20])[CH:16]=3)[C:11]2=[O:21])[CH2:3][CH2:2]1

Participants

4

Reactant 3

HCID 1118Sulfuric AcidHCID 24434Potassium NitrateHCID 66802250HCID 66802250, compound

Product 1

HCID 68094409HCID 68094409, compoundYield 49.2%

Procedure

2-(4-Cyclopropylpyridin-3-yl)-6-fluoro-3,4-dihydroisoquinolin-1(2H)-one (81A: 700 mg, 2.482 mmol) was reacted with conc. H2SO4 (5 mL) and KNO3 (276 mg, 2.73 mmol) for 4 hours to afford 400 mg of the product (49.14% yield).

Sources & evidence

ORD record
ord-148a797981e742dcb3b85e7f014de89e
Source dataset
uspto-grants-2015_02
Patent number
US08946260B2

Reaction notes

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