HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → HCID 66801567, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | HCID 68094409 | HCID 68094409 | — |
| Catalyst | Iron | HCID 23925 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 66801567 | HCID 66801567 | 96.6% |
Reaction Steps
2-(4-Cyclopropylpyridin-3-yl)-6-fluoro-7-nitro-3,4-dihydroisoquinolin-1(2H)-one (I-82a: 400 mg, 1.219 mmol) was reduced with iron powder (340 mg, 6.09 mmol) and acetic acid (10 mL) in THF (10 mL) at 75° C. for 4 hours to afford 350 mg of the product (96.6% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08946260B2 |
| Source dataset | uspto-grants-2015_02 |
| ORD ID | ord-151ea2bf4df247529282b9d303059210 |
| Source note | uspto-grants-2015_02 |