Potassium Phosphate, Tribasic → HCID 66802002, compound

Participants

Reaction Steps

6-Fluoro-3,4-dihydroisoquinolin-1(2H)-one (I-78d: 250 mg, 1.5146 mmol) was reacted with 3-iodo-4-methyl-pyridine (365 mg, 1.66 mmol), 1,4-dioxane (10 mL), copper iodide (29 mg, 0.151 mmol), trans-N,N′-dimethyl-cyclohexyl-1,2-diamine (21.5 mg, 0.151 mmol) and potassium phosphate (965 mg, 4.54 mmol) for 14 hours at 120° C. to afford the crude product. Purification by column chromatography on silica gel (2% methanol in CHCl3) afforded 350 mg of the product (90.4% yield).

Provenance & Evidence