HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Azide → HCID 66801981, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Azide | HCID 33557 | — |
| Reactant | HCID 66803491 | HCID 66803491 | — |
| Solvent | Trifluoroacetic acid | HCID 6422 | — |
| Product | HCID 66801981 | HCID 66801981 | 54.8% |
Reaction Steps
5-Chloro-6-(trifluoromethyl)-2,3-dihydro-1H-inden-1-one (I-85d: 600 mg, 2.5575 mmol) in TFA (25 mL) was reacted with sodium azide (549 mg, 8.439 mmol) for 5 hours at 80° C. Purification by column chromatography on silica gel (1% methanol in CHCl3), afforded 350 mg of the product (54.8% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08946260B2 |
| Source dataset | uspto-grants-2015_02 |
| ORD ID | ord-178e550a38504d97a875d443bbea3512 |
| Source note | uspto-grants-2015_02 |