Potassium Phosphate, Tribasic → HCID 56940826, compound

Participants

Reaction Steps

6-Chloro-7-(trifluoromethyl)-3,4-dihydroisoquinolin-1(2H)-one (I-85e: 100 mg, 0.4 mmol) was reacted with 3-bromo-4-(trifluoromethyl)-pyridine (117.6 mg, 0.520 mmol), 1,4-dioxane (5 mL), copper iodide (7.6 mg, 0.04 mmol), trans-N,N′-dimethyl-cyclohexyl-1,2-diamine (5.6 mg, 0.04 mmol) and potassium phosphate (255.6 mg, 1.2 mmol) to afford the crude product. Purification by preparative HPLC afforded 15 mg of the product (10% yield).

Provenance & Evidence