Potassium Phosphate, Tribasic → HCID 56940827, compound

Participants

Reaction Steps

7-Chloro-6-methoxy-3,4-dihydroisoquinolin-1(2H)-one (I-86d: 200 mg, 0.946 mmol) was reacted with 3-iodo-4-methylpyridine (228.2 mg, 1.042 mmol), 1,4-dioxane (5 mL), copper iodide (18 mg, 0.094 mmol), trans-N,N′-dimethyl-cyclohexyl-1,2-diamine (13.4 mg, 0.095 mmol) and potassium phosphate (603.3 mg, 2.84 mmol) for 48 hours at 120° C. to afford the crude product. Purification by column chromatography on silica gel (2% methanol in CHCl3) afforded 150 mg of the product (52.4% yield).

Provenance & Evidence