Potassium Phosphate, Tribasic → HCID 56940969, compound

Participants

Reaction Steps

7-Chloro-6-methoxy-3,4-dihydroisoquinolin-1(2H)-one 100 mg, 0.473 mmol) was reacted with 4-cyclopropyl-3-iodopyridine (I-73c: 127.6 mg, 0.521 mmol), 1,4-dioxane (5 mL), copper iodide (9.3 mg, 0.047 mmol), trans-N,N′-dimethyl-cyclohexyl-1,2-diamine (6.7 mg, 0.047 mmol) and potassium phosphate (301.6 mg, 1.421 mmol) for 12 hours at 120° C. to afford the crude product. Purification by column chromatography on silica gel (2% methanol in CHCl3), followed by preparative HPLC afford 35 mg of the product

Provenance & Evidence