1,1,1-Trifluoro-N-phenylmethanesulfonamide → HCID 87158322, compound

Participants

Reaction Steps

7-Chloro-6-hydroxy-2-(4-cyclopropylpyridin-3-yl)-3,4-dihydroisoquinolin-1(2H)-one (90A: 180 mg, 0.57 mmol) was reacted with KHMDS (0.71 mL, 0.71 mmol) in THF (10 mL) and N-phenyl trifluoromethanesulfonamide (226 mg, 0.630 mmol) to afford the crude product. Purification by column chromatography on silica gel (1% methanol in CHCl3) afforded 170 mg of the product (66.6% yield).

Provenance & Evidence