HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → HCID 56940970, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | HCID 87158322 | HCID 87158322 | — |
| Catalyst | Zinc cyanide (Zn(CN)2) | HCID 11186 | — |
| Catalyst | Ferrocene-1,1'-bis-(diphenylphosphine) | HCID 635956 | — |
| Catalyst | Bis(dibenzylideneacetone)palladium | HCID 9811564 | — |
| Product | HCID 56940970 | HCID 56940970 | 24.3% |
Reaction Steps
7-Chloro-2-(4-cyclopropylpyridin-3-yl)-1-oxo-1,2,3,4-tetrahydroisoquinolin-6-yl trifluoromethanesulfonate (I-91a: 170 mg, 0.381 mmol) in DMF (3 mL) was reacted with Pd2(dba)3 (6.97 mg, 0.007 mmol), dppf (16.9 mg, 0.003 mmol) and Zn(CN)2 (26.8 mg, 0.228 mmol) for 24 hours at 80° C. to afford the crude product. Purification by column chromatography on silica gel (2% methanol in CHCl3) followed by preparative HPLC afforded 30 mg of the product (24.3% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08946260B2 |
| Source dataset | uspto-grants-2015_02 |
| ORD ID | ord-e8b912dad741495abf1006cd325390c0 |
| Source note | uspto-grants-2015_02 |