Sodium hydride → HCID 67973797, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of ethyl 5-fluoro-1-oxo-indane-2-carboxylate (1.4 g, 6.3 mmol), sodium hydride (278 mg, 6.9 mmol, 60% in mineral oil) and DMF (dry, 2.5 ml) was heated to 65° C. for one hour. A solution of bromo ethylester (1.15 g, 0.8 ml, 6.9 mmol) in dry DMF (4.0 ml) was added at the same temperature and heating was continued for additional 3 h. After complete the reaction, reaction mass was evaporated to dryness, 5 ml water was added and the suspension was extracted with ethyl acetate (25 ml×3). Combined organic layer was washed with brine, dried over sodium sulphate, evaporated and subjected to column chromatography using ethyl acetate/hexane (15%) to yield a desired product (1.3 g, 72%).

Provenance & Evidence