Acetate-hydrochloric acid → HCID 10443021, compound

Participants

Reaction Steps

Ethyl 2-(2-ethoxy-2-oxo-ethyl)-5-fluoro-1-oxo-indane-2-carboxylate (500 mg, 1.6 mmol) was suspended in 1.4 ml mixture of 6 N HCl: acetic acid (1:1) and heated to reflux for 3 h. Reaction was monitored by TLC. Reaction mass was evaporated to dryness, 10 ml water was added and extracted with ethyl acetate (40 ml×3). Organic layer was washed with sat brine, dried over sodium sulphate. Crude product was washed with hexane to obtain a desired product (280 mg, 82%).

Provenance & Evidence