Toluene → HCID 67989354, compound

Participants

Reaction Steps

A solution tert-butyl 8-bromo-2-oxo-3,3a,4,8b-tetrahydroindeno[1,2-b]pyrrole-1-carboxylate (Example F10, 700 mg), Pd(PPh3)4 (280 mg, 0.12 equiv.), allyltributylstannate (1.65 g, 2.5 equiv.) in toluene (17 mL) was degassed and stirred at reflux over night. The solvent was removed under vacuum. The residue was taken up in acetonitrile (40 mL) and washed twice with n-hexane. The acetonitrile was removed in vacuo and the residue was purified by flash chromatography eluting with ethyl acetate and cyclohexane (1 to 25%) to give 350 mg of the desired products (mixture of allyl and isomer) F14: LCMS (method E), RT: 1.06 min, [ES+[377, M+CH3CN+Na].

Provenance & Evidence