1-Chloro-4-iodobenzene → HCID 67975703, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of tetrahydro-1H-indeno[1,2-b]pyrrol-2-one (1.00 g, 5.77 mmol) in water (3 mL) was added copper (I) oxide (167 mg), p-chloroiodobenzene (1.38 g, 5.77 mmol), tetrabutylammonium bromide (0.372 g, 1.15 mmol) and potassium phosphate (2.45 g, 11.5 mmol). The suspension was vigorously stirred at 130° C. overnight. The mixture was cooled down and diluted with dichloromethane. The solid were filtered off and the organic layer was dried and concentrated. The residue was purified by flash chromatography with a gradient of ethyl acetate in cyclohexane of 1 to 60%, to give the desired product F16 (600 mg, 39%). LCMS (method A) 1.72 min; ES+: 284 (M+H+).

Provenance & Evidence