Water → 2-(4-Fluorophenyl)-5-(4-methoxy-2-methyl-5-(1-(pyridin-2-yl)cyclopropylcarbamoyl)phenyl)-N-methylbenzofuran-3-carboxamide

HRID 184409Notes

Reaction equation

HRID 184409 reaction equation
[Br:1][c:2]1[c:3]([CH3:22])[cH:4][c:5]([O:20][CH3:21])[c:6]([C:7](=[O:8])[NH:9][C:10]2([c:13]3[n:14][cH:15][cH:16][cH:17][cH:18]3)[CH2:11][CH2:12]2)[cH:19]1.[C:58](=[O:59])([O-:60])[O-:61].[Cl:64][CH2:65][Cl:66].[Cs+:62].[Cs+:63].[F:29][c:30]1[cH:31][cH:32][c:33](-[c:36]2[o:37][c:38]3[c:39]([c:40]2[C:41](=[O:42])[NH:43][CH3:44])[cH:45][c:46]([B:49]2[O:50][C:51]([CH3:52])([CH3:53])[C:54]([CH3:55])([CH3:56])[O:57]2)[cH:47][cH:48]3)[cH:34][cH:35]1.[O:23]1[CH2:24][CH2:25][O:26][CH2:27][CH2:28]1.[OH2:144].[cH:67]1[cH:68][cH:69][c:70]([P:71]([Pd:72]([P:73]([c:74]2[cH:75][cH:76][cH:77][cH:78][cH:79]2)([c:80]2[cH:81][cH:82][cH:83][cH:84][cH:85]2)[c:86]2[cH:87][cH:88][cH:89][cH:90][cH:91]2)([P:92]([c:93]2[cH:94][cH:95][cH:96][cH:97][cH:98]2)([c:99]2[cH:100][cH:101][cH:102][cH:103][cH:104]2)[c:105]2[cH:106][cH:107][cH:108][cH:109][cH:110]2)[P:111]([c:112]2[cH:113][cH:114][cH:115][cH:116][cH:117]2)([c:118]2[cH:119][cH:120][cH:121][cH:122][cH:123]2)[c:124]2[cH:125][cH:126][cH:127][cH:128][cH:129]2)([c:130]2[cH:131][cH:132][cH:133][cH:134][cH:135]2)[c:136]2[cH:137][cH:138][cH:139][cH:140][cH:141]2)[cH:142][cH:143]1>>[c:2]1(-[c:46]2[cH:45][c:39]3[c:38]([o:37][c:36](-[c:33]4[cH:32][cH:31][c:30]([F:29])[cH:35][cH:34]4)[c:40]3[C:41](=[O:42])[NH:43][CH3:44])[cH:48][cH:47]2)[c:3]([CH3:22])[cH:4][c:5]([O:20][CH3:21])[c:6]([C:7](=[O:8])[NH:9][C:10]2([c:13]3[n:14][cH:15][cH:16][cH:17][cH:18]3)[CH2:11][CH2:12]2)[cH:19]1

Participants

9

Reactant 8

HCID 962WaterHCID 6344DichloromethaneHCID 19660Carbonate IonHCID 312751,4-DioxaneHCID 104967Cesium cation2×HCID 592754752-(4-fluorophenyl)-N-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzofuran-3-carboxamideHCID 672118695-bromo-2-methoxy-4-methyl-N-(1-(pyridin-2-yl)cyclopropyl)benzamideHCID 178420554HCID 178420554, compound

Product 1

HCID 592757562-(4-Fluorophenyl)-5-(4-methoxy-2-methyl-5-(1-(pyridin-2-yl)cyclopropylcarbamoyl)phenyl)-N-methylbenzofuran-3-carboxamide

Sources & evidence

ORD record
ord-8a2adc65873e486b9c8a63932237184b
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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