HCID 67975594, compound → HCID 67975561, compound

Participants

Reaction Steps

A solution of the 2-oxo-3,3a,4,8b-tetrahydro-2H-indeno[1,2-b]pyrrole-1-carboxylic acid tert-butyl ester F1 (160 mg, 0.586 mmol) in tert-butoxybis(dimethylamino)methane was heated at 75° C. for 4 h. The solution was diluted with ethyl acetate and washed with water, brine, dried and concentrated to give 3-[1-dimethylamino-meth-(Z)-ylidene]-2-oxo-3,3a,4,8b-tetrahydro-2H-indeno[1,2-b]pyrrole-1-carboxylic acid tert-butyl ester E1 (colourless solid, 190 mg, 98%). C19H24N2O3; MW: 328.41; LCMS (method A) RT 1.78 min; ES: 329 (MH+), 273; 1H NMR (400 MHz, CDCl3) δ 7.74 (1H, d), 7.15-7.26 (4H, m), 5.61 (1H, d), 3.99 (1H, td), 3.37 (1H, dd), 3.10 (6H, s), 3.06 (1H, dd), 1.60 (9H, s) ppm.

Provenance & Evidence