Trifluoroacetic acid → HCID 67975417, compound

Participants

Reaction Steps

A solution of 3-[1-hydroxy-meth-(Z)-ylidene]-2-oxo-3,3a,4,8b-tetrahydro-2H-indeno[1,2-b]pyrrole-1-carboxylic acid tert-butyl ester D1 (0.400 g, 1.32 mmol) in dichloromethane (20 mL) was added trifluoroacetic acid (2 mL) at 0° C. The solution was stirred for 1 h. A saturated solution of sodium hydrogenocarbonate was added and the aqueous layer was extracted with dichloromethane. The combined organic layers were washed with a saturated solution of sodium hydrogenocarbonate, dried and concentrated in vacuo to give 3-[1-Hydroxy-meth-(Z)-ylidene]-3,3a,4,8b-tetrahydro-1H-indeno[1,2-b]pyrrol-2-one C1 (White solid, 271 mg, quant.). C12H11NO2; MW: 201.23; LCMS (method A) RT 1.18 min; ES: 256 (MH++MeCN), 224 (MNa+), 202 (MH+); IR: 3264, 1678 cm−1; 1H NMR (400 MHz, DMSO-d6) δ 10.00 (1H, s), 7.16-7.38 (4H, m), 7.13 (1H, d), 4.94 (1H, d), 3.68-3.82 (1H, m), 3.31 (2H, dd), 3.01 (1H, dd) ppm.

Provenance & Evidence