Ethanol → HCID 89858026, compound

Participants

Reaction Steps

A catalytic amount of pyrrolidine (0.001 mmol) was added to compound D75 (1 mmol) and pyrrole-2-carbaldehyde (1.2 mmol) in ethanol (5 mL). After addition the reaction was carried out using microwave (CEM, Discover) at 100° C. (200 W: Standard mode) for 15 mins. Crude product was precipitated after cooling to RT, collected by filtration, washed with ethanol and air dried. YD: 55.06%; mp: 267-272° C. (charring). 1H NMR (400 MHz, DMSO-d6) δ: 2.788 (s, 3H), 3.420 (t, J=8.2 Hz, 2H), 3.766 (t, J=8.2 Hz, 2H), 6.320 (br, J=3.2 Hz, 1H), 6.767 (br, 1H), 6.879 (dd, J=1.6 & 8.4 Hz, 1H), 7.301 (br, 1H), 7.320 (br, 1H), 7.526 (d, J=8.0 Hz, 1H), 7.599 (s, 1H), 10.480 (s, 1H), 10.872 (s, 1H), 13.198 (s, 1H). (C18H17N5O3) C, H, N.

Provenance & Evidence