HCID 86718179, compound → HCID 86718178, compound

HRID 1844154Notes

Reaction equation

HRID 1844154 reaction equation
C([O:8][C:9]1[C:10]2[N:11]([C:15]([C:19]([NH:21][C@H:22]([CH2:25][CH3:26])[CH2:23][OH:24])=[O:20])=[C:16]([CH3:18])[N:17]=2)[CH:12]=[CH:13][CH:14]=1)C1C=CC=CC=1>[Pd]>[OH:8][C:9]1[C:10]2[N:11]([C:15]([C:19]([NH:21][C@H:22]([CH2:25][CH3:26])[CH2:23][OH:24])=[O:20])=[C:16]([CH3:18])[N:17]=2)[CH:12]=[CH:13][CH:14]=1

Participants

3

Reactant 1

HCID 86718179HCID 86718179, compound

Product 1

HCID 86718178HCID 86718178, compound

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

The preparation was carried out analogously to Example 46A by Pd/C-mediated hydrogenation starting with 3.5 g (about 9.72 mmol) of 8-(benzyloxy)-N-[(2R)-1-hydroxybutan-2-yl]-2-methylimidazo[1,2-a]pyridine-3-carboxamide. This gave 1.2 g (58% of theory) of the title compound.

Sources & evidence

ORD record
ord-4f08c35000e14951b3125d3afe5b493c
Source dataset
uspto-grants-2015_02
Patent number
US08946215B2

Reaction notes

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