HCID 86717937, compound → 2-Amino-4-fluoropyridin-3-ol

HRID 1844177Notes

Reaction equation

HRID 1844177 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]([N+:8]([O-])=O)[C:3]=1[OH:11]>C(O)C.[Pd]>[NH2:8][C:4]1[C:3]([OH:11])=[C:2]([F:1])[CH:7]=[CH:6][N:5]=1

Participants

4

Reactant 1

HCID 86717937HCID 86717937, compound

Product 1

HCID 214366942-Amino-4-fluoropyridin-3-ol

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

Under argon, 90 mg (0.57 mmol) of 4-fluoro-2-nitropyridin-3-ol Example 108A were dissolved in 30 ml of ethanol, and a spatula tip of palladium on activated carbon (10%) was added. The mixture was hydrogenated at RT under reduced pressure for 1.5 h. The reaction mixture was filtered off through silica gel and the filter cake was washed with plenty of ethanol. The solution was concentrated and dried. This gave 56 mg (77% of theory) of the title compound.

Workup

  1. filtrationThe reaction mixture was filtered off through silica gel
  2. washthe filter cake was washed with plenty of ethanol
  3. concentrationThe solution was concentrated
  4. customdried

Sources & evidence

ORD record
ord-cbab8d5f4d61433c9dcdd70c60f34f90
Source dataset
uspto-grants-2015_02
Patent number
US08946215B2

Reaction notes

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