Hydrochloric Acid → HCID 86718227, compound

Participants

Reaction Conditions

Reaction Steps

28.1 ml (28.1 mmol) 1 M lithium hydroxide solution were added to 2.0 g (5.62 mmol) of ethyl 6-chloro-8-[(3-fluoropyridin-2-yl)methoxy]-2-methylimidazo[1,2-a]pyridine-3-carboxylate from Example 128A, and the mixture was stirred at 40° C. for 2.5 h. The reaction mixture, cooled to RT, was adjusted to about pH 4 using 6 N aqueous hydrochloric acid, the solvent was concentrated to half its original volume and the precipitated solid was filtered off with suction and dried under reduced pressure. This gave 1.97 g (102% of theory) of the target compound (a proportion possibly as hydrochloride salt).

Provenance & Evidence