Water → HCID 86717935, compound

Participants

Reaction Steps

10 g (42.69 mmol) of ethyl 8-hydroxy-2,6-dimethylimidazo[1,2-a]pyridine-3-carboxylate from Example 87A, 10.9 g (46.96 mmol) of 2-(bromomethyl)-1,3,4-trifluorobenzene and 30.6 g (93.91 mmol) of caesium carbonate were initially charged in 611 ml of DMF, and the mixture was heated in an oil bath, preheated to 60° C., for 30 min. The reaction mixture was poured into about 5 l of water and stirred for 30 min, and the solid formed was filtered off with suction, washed with water and dried under high vacuum. This gave 14.1 g of the target compound (86% of theory).

Provenance & Evidence