Hydrochloric Acid → HCID 86717936, compound

Participants

Reaction Conditions

Reaction Steps

6.9 g (17.51 mmol) of ethyl 2,6-dimethyl-8-[(2,3,6-trifluorobenzyl)oxy]imidazo[1,2-a]pyridine-3-carboxylate from Example 145A were dissolved in 374 ml of THF/methanol (5/1), 87.5 ml (87.5 mmol) of 1 N aqueous lithium hydroxide solution were added and the mixture was stirred at 40° C. for 5 hours. After cooling, the mixture was acidified, with ice-cooling, with 6 N aqueous hydrochloric acid, and the organic solvent was then removed on a rotary evaporator. The solid formed was filtered off with suction, washed with water and then dried under high vacuum. This gave 6.7 g of the target compound (108% of theory).

Provenance & Evidence