Sodium Hydroxide → HCID 67114764, compound

Participants

Reaction Steps

NaOH (6 N aqueous solution, 10 mL) was added to a solution of (trans)-ethyl 2-(4-(allyloxy)phenyl)cyclopropanecarboxylate (Intermediate F, 11.15 g, 45.27 mmol) in methanol (30 mL) and THF (25 mL) and stirred at room temperature for 18 h. After removal of the solvent, the residue was dissolved in CH2Cl2 (200 mL), acidified with HCl (10% aqueous solution, 30 mL), and washed with brine (2×200 mL). The organic layer was dried over anhydrous Na2SO4 and filtered. Removal of the solvent afforded 9.13 of (trans)-2-[4-(allyloxy)phenyl]cyclopropanecarboxylic acid [Rf=0.25 (5% MeOH/CH2Cl2), white solid, 92% yield]

Provenance & Evidence