Sodium Iodide → Tert-butyl(trans)-2-{4-[(4-cyanobenzyl)oxy]phenyl}cyclopropylcarbamate

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Reaction Steps

4-(bromomethyl)benzonitrile (0.47 g, 2.40 mmol) was added to a mixture of Intermediate J, tert-butyl(trans)-2-(4-hydroxyphenyl)cyclopropylcarbamate, (0.50 g, 2.00 mmol), K2CO3 (0.42 g, 3.00 mmol) and NaI (0.03 g, 0.20 mmol) in acetone (15 mL) and stirred at room temperature for 3 d. After removal of the solvent, the crude residue was dissolved in EtOAc (30 mL) and washed with brine (2×25 mL). The organic layer was dried over anhydrous Na2SO4 and filtered. After removal of the solvent, the residue was purified by column chromatography on silica gel (5%-50% EtOAc/Hexanes), affording 0.52 g of tert-butyl(trans)-2-{4-[(4-cyanobenzyl)oxy]phenyl}cyclopropylcarbamate [Rf=0.2 (30% EtOAc/Hexanes), pale yellow solid, 71% yield].

Provenance & Evidence