Potassium Carbonate → HCID 52920397, compound

Participants

Reaction Steps

A solution of 2-((trans)-2-(4-bromophenyl)cyclopropylamino)acetamide (100 mg, 0.37 mmol, 1 equiv), 3-trifluoro methyl benzene boronic acid (84 mg, 0.44 mmol 1.2 equiv), K2CO3 (152 mg, 1.11 mmol, 3 equiv) in CH3CN+H2O (4:1) (2 mL) was degassed for 30 min with Argon gas, then Pd(PPh3)4 (0.1 equiv) was added and the reaction mixture was heated at reflux temp. for 2 h. After completion, the reaction mixture was poured into ice water (10 mL), extracted with EtOAc (2×10 mL). The combined extracts were washed with water (10 mL), brine (10 mL), dried over anhydrous Na2SO4, filtered and evaporated. The crude residue was purified by prep HPLC to give 2-((trans)-2-(3′-(trifluoromethyl)biphenyl-4-yl)cyclopropylamino)acetamide (100 mg, 80% yield) as a white solid.

Provenance & Evidence