tert-Butyl (2S)-2-(aminomethyl)pyrrolidine-1-carboxylate → HCID 86697431, compound

HRID 1844343Notes

Reaction equation

HRID 1844343 reaction equation
Cl[C:2]1[CH:7]=[CH:6][N:5]2[N:8]=[CH:9][CH:10]=[C:4]2[N:3]=1.[NH2:11][CH2:12][C@@H:13]1[CH2:17][CH2:16][CH2:15][N:14]1[C:18]([O:20][C:21]([CH3:24])([CH3:23])[CH3:22])=[O:19]>>[N:8]1[N:5]2[CH:6]=[CH:7][C:2]([NH:11][CH2:12][C@@H:13]3[CH2:17][CH2:16][CH2:15][N:14]3[C:18]([O:20][C:21]([CH3:24])([CH3:23])[CH3:22])=[O:19])=[N:3][C:4]2=[CH:10][CH:9]=1

Participants

3

Reactant 2

HCID 1512533tert-Butyl (2S)-2-(aminomethyl)pyrrolidine-1-carboxylateHCID 210717595-Chloropyrazolo(1,5-a)pyrimidine

Product 1

HCID 86697431HCID 86697431, compoundYield 96%

Procedure

The commercially available 5-chloropyrazolo[1,5-a]pyrimidine is reacted with (S)-tert-butyl 2-(aminomethyl)pyrrolidine-1-carboxylate under the amine displacement conditions described in example 5.6.5 to give 96% product.

Sources & evidence

ORD record
ord-ff96dbd60f9248a1a5fb84dd620b4c2f
Source dataset
uspto-grants-2015_02
Patent number
US08946415B2

Reaction notes

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