HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → 2,4,5-Trifluoro-3-methoxybenzoyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 2,4,5-Trifluoro-3-methoxybenzoic acid | HCID 2733970 | — |
| Product | 2,4,5-Trifluoro-3-methoxybenzoyl chloride | HCID 2775281 | — |
Reaction Steps
A mixture of 2,4,5-trifluoro-3-methoxybenzoic acid (154 mg, 0.75 mmol) and thionyl chloride (8 mL) is refluxed for 4 h. Excess thionyl chloride is removed in vacuo, and the remaining residue is used directly in the next synthetic step.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08946422B2 |
| Source dataset | uspto-grants-2015_02 |
| ORD ID | ord-d8bd22cc7a604f0ea2f8c25d160b063b |
| Source note | uspto-grants-2015_02 |