HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → 2,4-Difluoro-3-methoxybenzoyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 2,4-Difluoro-3-methoxybenzoic acid | HCID 3780555 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 2,4-Difluoro-3-methoxybenzoyl chloride | HCID 3850619 | — |
Reaction Steps
A mixture of 2,4-difluoro-3-methoxybenzoic acid (2.1 g, 11.1 mmol), thionyl chloride (5 mL), and ethyl acetate (30 mL) is refluxed for 4 h. All volatiles are removed in vacuo, and the remaining residue is used directly in the next synthetic step.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08946422B2 |
| Source dataset | uspto-grants-2015_02 |
| ORD ID | ord-c3b7e884de4f4ff6b9683aab078298c7 |
| Source note | uspto-grants-2015_02 |