Water → HCID 86731078, compound

Participants

Reaction Steps

3,4-Dichlorobenzenethiol (500 mg, 2.79 mmol) and 2-(3-bromopropyl)isoindoline-1,3-dione (823 mg, 3.07 mmol) were stirred in DMF (2 mL) at rt. Cs2CO3 (1.64 g, 5.03 mmol) was added. The reaction mixture was stirred at rt for 14 h. H2O was added and the aqueous phase was extracted with EtOAc. The organic layer was dried over MgSO4, filtered and concentrated to give crude product. It was then triturated with ether to yield a white precipitate which was filtered and dried to give Intermediate 7A (760 mg, 2.075 mmol, 74.3% yield). LC-MS (ESI) 365.8 (M+H). RT=4.00 min (Method A).

Provenance & Evidence