Methanol → HCID 86730079, compound

Participants

Reaction Steps

To a solution of 3,4-dichlorobenzene-1-sulfonyl chloride (470 mg, 1.91 mmol) was added tert-butyl piperidin-4-ylmethylcarbamate (410 mg, 1.91 mmol), followed by triethylamine (0.267 mL, 1.91 mmol). The reaction mixture was stirred overnight then diluted with DCM. The organic phase was washed with 1N HCl, H2O, and brine, dried over Na2SO4, then filtered. The solvent was evaporated under reduced pressure and the residue was purified on a 24 g cartridge using 0 to 100% EtOAc in Hexane and then 0 to 20% MeOH in DCM to yield Intermediate 8A (800 mg, 1.89 mmol, 99% yield). LC-MS (ESI) 324.1. (M+H-Boc), RT=1.55 min (Method B).

Provenance & Evidence