2-Trifluoromethylphenol → HCID 28937407, compound

HRID 1844408Notes

Reaction equation

HRID 1844408 reaction equation
Cl[C:2]1[CH:13]=[CH:12][CH:11]=[C:10](Cl)[C:3]=1[O:4][CH2:5][CH2:6][C@H:7]([NH2:9])[CH3:8].[F:15][C:16]([F:25])([F:24])C1C=CC=CC=1O>>[F:15][C:16]([F:25])([F:24])[C:2]1[CH:13]=[CH:12][CH:11]=[CH:10][C:3]=1[O:4][CH2:5][CH2:6][C@H:7]([NH2:9])[CH3:8]

Participants

3

Reactant 2

HCID 679582-TrifluoromethylphenolHCID 86731080HCID 86731080, compound

Product 1

HCID 28937407HCID 28937407, compoundYield 88%

Procedure

Intermediate 14 (55 mg, 0.250 mmol, 88% yield) was prepared as a white powder following the procedure described for Intermediate 13 by replacing 2,6-dichlorophenol with 2-trifluoromethylphenol. LC-MS (ESI) 221 (M+H), RT=1.48 min (Method B).

Sources & evidence

ORD record
ord-8d454a91818b410c8c2cc1c5e6ccb647
Source dataset
uspto-grants-2015_02
Patent number
US08946430B2

Reaction notes

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