1-Isopropyl-1H-indole-2,3-dione → HCID 86731082, compound

HRID 1844414Notes

Reaction equation

HRID 1844414 reaction equation
OC1C(=O)N(C)C2C([C:11]=1[C:12]([O:14][CH2:15][CH3:16])=[O:13])=CC=CC=2.[CH:19]([N:22]1[C:30]2[C:25](=[CH:26][CH:27]=[CH:28][CH:29]=2)[C:24](=[O:31])[C:23]1=[O:32])([CH3:21])[CH3:20]>>[OH:31][C:24]1[C:23](=[O:32])[N:22]([CH:19]([CH3:20])[CH3:21])[C:30]2[C:25]([C:11]=1[C:12]([O:14][CH2:15][CH3:16])=[O:13])=[CH:26][CH:27]=[CH:28][CH:29]=2

Participants

3

Reactant 2

HCID 20550491-Isopropyl-1H-indole-2,3-dioneHCID 86731081HCID 86731081, compound

Product 1

HCID 86731082HCID 86731082, compound

Procedure

Intermediate 19 was prepared as a white powder following the procedure described for Intermediate 16 by replacing indoline-2,3-dione with 1-isopropylindoline-2,3-dione. 1H NMR (400 MHz, chloroform-d) δ ppm 8.10 (1 H, br. s.), 7.77 (1 H, d, J=7.8 Hz), 7.60 (1 H, d, J=8.3 Hz), 7.42 (1 H, t, J=7.7 Hz), 7.27 (1 H, t, J=7.5 Hz), 4.53 (2 H, q, J=7.1 Hz), 1.45 (3 H, t, J=7.1 Hz). LC-MS (ESI) m/z 276.0 (M+H), RT=1.93 min (Method B)

Sources & evidence

ORD record
ord-5ae3ec87436545bd8112526e89bd4b11
Source dataset
uspto-grants-2015_02
Patent number
US08946430B2

Reaction notes

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