5-Fluoroisatin → HCID 54741616, compound

HRID 1844415Notes

Reaction equation

HRID 1844415 reaction equation
[OH:1][C:2]1[C:3](=[O:18])[N:4](C)[C:5]2[C:10]([C:11]=1[C:12]([O:14][CH2:15][CH3:16])=[O:13])=[CH:9][CH:8]=[CH:7][CH:6]=2.[F:19]C1C=C2C(=CC=1)NC(=O)C2=O>>[F:19][C:8]1[CH:9]=[C:10]2[C:5](=[CH:6][CH:7]=1)[NH:4][C:3](=[O:18])[C:2]([OH:1])=[C:11]2[C:12]([O:14][CH2:15][CH3:16])=[O:13]

Participants

3

Reactant 2

HCID 2365665-FluoroisatinHCID 86731081HCID 86731081, compound

Product 1

HCID 54741616HCID 54741616, compound

Procedure

Intermediate 21 was prepared as a white powder following the procedure described for Intermediate 16 by replacing indoline-2,3-dione with 5-fluoroindoline-2,3-dione. LC-MS (ESI) m/z 251.9 (M+H), RT=1.74 min (Method B).

Sources & evidence

ORD record
ord-f03def2982bf454ca5b76f44f1a47f06
Source dataset
uspto-grants-2015_02
Patent number
US08946430B2

Reaction notes

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