HCID 86731081, compound → HCID 72702341, compound

HRID 1844416Notes

Reaction equation

HRID 1844416 reaction equation
[OH:1][C:2]1[C:3](=[O:18])[N:4](C)[C:5]2[C:10]([C:11]=1[C:12]([O:14][CH2:15][CH3:16])=[O:13])=[CH:9][CH:8]=[CH:7][CH:6]=2.[F:19][C:20]([F:40])([F:39])[O:21]C1C=CC(N2C3C(=CC=CC=3)C(=O)C2=O)=CC=1>>[OH:1][C:2]1[C:3](=[O:18])[NH:4][C:5]2[C:10]([C:11]=1[C:12]([O:14][CH2:15][CH3:16])=[O:13])=[CH:9][C:8]([O:21][C:20]([F:40])([F:39])[F:19])=[CH:7][CH:6]=2

Participants

3

Reactant 2

HCID 86731081HCID 86731081, compoundHCID 86731084HCID 86731084, compound

Product 1

HCID 72702341HCID 72702341, compound

Procedure

Intermediate 23 was prepared as a white powder following the procedure described for Intermediate 16 by replacing indoline-2,3-dione with 4-trifluoromethoxy-phenylindoline-2,3-dione. 1H NMR (400 MHz, chloroform-d) δ ppm 11.90 (1 H, br. s.), 11.28 (1 H, br. s.), 8.22 (1 H, br. s.), 7.36-7.53 (1 H, m), 7.43 (1 H, br. s.), 4.61 (2 H, d, J=7.1 Hz), 1.54 (3 H, t, J=6.9 Hz). LC-MS (ESI) m/z 317.9 (M+H), RT=2.00 min (Method B).

Sources & evidence

ORD record
ord-f74d13d7afd14d6b8a9ee7648667797b
Source dataset
uspto-grants-2015_02
Patent number
US08946430B2

Reaction notes

Loading…