HCID 53359242, compound → HCID 86731085, compound

HRID 1844417Notes

Reaction equation

HRID 1844417 reaction equation
[OH:1][C:2]1[C:3](=[O:18])[N:4](C)[C:5]2[C:10]([C:11]=1[C:12]([O:14][CH2:15][CH3:16])=[O:13])=[CH:9][CH:8]=[CH:7][CH:6]=2.[I:19]C1C=CC(N2C3C(=CC=CC=3)C(=O)C2=O)=CC=1>>[OH:1][C:2]1[C:3](=[O:18])[NH:4][C:5]2[C:10]([C:11]=1[C:12]([O:14][CH2:15][CH3:16])=[O:13])=[CH:9][C:8]([I:19])=[CH:7][CH:6]=2

Participants

3

Reactant 2

HCID 53359242HCID 53359242, compoundHCID 86731081HCID 86731081, compound

Product 1

HCID 86731085HCID 86731085, compound

Procedure

Intermediate 26 was prepared as a white powder the procedure described for Intermediate 16 by replacing indoline-2,3-dione with 4-iodo-phenylindoline-2,3-dione. 1H NMR (400 MHz, DMSO-d6) δ ppm 12.41 (1 H, br. s.), 10.52 (1 H, br. s.), 7.33-8.21 (2 H, m), 7.14 (1 H, d, J=8.3 Hz), 4.41 (2 H, q, J=6.9 Hz), 3.34 (1 H, br. s.), 2.51 (1 H, br. s.), 1.33 (3 H, t, J=7.1 Hz). LC-MS (ESI) m/z 359.9 (M+H), RT=3.48 min (Method A).

Sources & evidence

ORD record
ord-de19b6f6dc2c4a30a8c4335b144f85b2
Source dataset
uspto-grants-2015_02
Patent number
US08946430B2

Reaction notes

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