(S)-benzyl 4-(3-(1-aminoethyl)phenyl)piperazine-1-carboxylate → (S)-benzyl 4-(3-(1-(3-hydroxy-1-methyl-2-oxo-1,2-dihydroquinoline-4-carboxamido)ethyl)phenyl)piperazine-1-carboxylate

Participants

Reaction Steps

Following the same procedure as described for Example 3, Example 205 was prepared as an off-white powder by using 3-hydroxy-1-methyl-2-oxo-1,2-dihydroquinoline-4-carbonyl chloride and (S)-benzyl 4-(3-(1-aminoethyl)phenyl)piperazine-1-carboxylate (Intermediate 34). LC-MS (ESI) m/z 541 (M+H), RT=2.00 min (Method B). Orthogonal HPLC (150×4.6 mm 3.5 μm, 254 nm): Sunfire {RT=8.9 min, 93%}; Xbridge {RT=8.5 min, 92%}.

Provenance & Evidence