3-Fluoroazetidine → 4-(3-Fluoro-azetidine-1-carbonyl)-2-methyl-2H-pyrazole-3-carboxylic acid (2-morpholin-4-yl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-amide

HRID 1844457Notes

Reaction equation

HRID 1844457 reaction equation
[F:1][CH:2]1[CH2:5][NH:4][CH2:3]1.[CH3:6][N:7]1[C:11]([C:12](=[O:29])[NH:13][C:14]2[CH:15]=[CH:16][C:17]3[N:18]([N:20]=[C:21]([N:23]4[CH2:28][CH2:27][O:26][CH2:25][CH2:24]4)[N:22]=3)[CH:19]=2)=[C:10]([C:30](O)=[O:31])[CH:9]=[N:8]1>>[N:23]1([C:21]2[N:22]=[C:17]3[CH:16]=[CH:15][C:14]([NH:13][C:12]([C:11]4[N:7]([CH3:6])[N:8]=[CH:9][C:10]=4[C:30]([N:4]4[CH2:5][CH:2]([F:1])[CH2:3]4)=[O:31])=[O:29])=[CH:19][N:18]3[N:20]=2)[CH2:24][CH2:25][O:26][CH2:27][CH2:28]1

Participants

3

Reactant 2

HCID 36035423-FluoroazetidineHCID 894643091-Methyl-5-(2-morpholino-[1,2,4]triazolo[1,5-a]pyridin-6-ylcarbamoyl)-1H-pyrazole-4-carboxylic acid

Product 1

HCID 715384154-(3-Fluoro-azetidine-1-carbonyl)-2-methyl-2H-pyrazole-3-carboxylic acid (2-morpholin-4-yl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-amide

Procedure

Using 3-fluoro-azetidine and 1-methyl-5-(2-morpholin-4-yl-[1,2,4]triazolo[1,5-a]pyridin-6-ylcarbamoyl)-1H-pyrazole-4-carboxylic acid, the title compound was prepared in the same manner as described for example 2. Off-white solid (150 mg, 76%). MS: m/z=429 (M+H+).

Sources & evidence

ORD record
ord-b71df60b2bf049769b4baff72c865c70
Source dataset
uspto-grants-2015_02
Patent number
US08946427B2

Reaction notes

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