3-Fluoroazetidine → 4-(3-Fluoro-azetidine-1-carbonyl)-2-methyl-2H-pyrazole-3-carboxylic acid (2-dimethylamino-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-amide

HRID 1844466Notes

Reaction equation

HRID 1844466 reaction equation
[F:1][CH:2]1[CH2:5][NH:4][CH2:3]1.[CH3:6][N:7]([CH3:29])[C:8]1[N:28]=[C:11]2[CH:12]=[CH:13][C:14]([NH:16][C:17]([C:19]3[N:23]([CH3:24])[N:22]=[CH:21][C:20]=3[C:25](O)=[O:26])=[O:18])=[CH:15][N:10]2[N:9]=1>>[CH3:6][N:7]([CH3:29])[C:8]1[N:28]=[C:11]2[CH:12]=[CH:13][C:14]([NH:16][C:17]([C:19]3[N:23]([CH3:24])[N:22]=[CH:21][C:20]=3[C:25]([N:4]3[CH2:5][CH:2]([F:1])[CH2:3]3)=[O:26])=[O:18])=[CH:15][N:10]2[N:9]=1

Participants

3

Reactant 2

HCID 36035423-FluoroazetidineHCID 894640535-(2-Dimethylamino-[1,2,4]triazolo[1,5-a]pyridin-6-ylcarbamoyl)-1-methyl-1H-pyrazole-4-carboxylic acid

Product 1

HCID 715386854-(3-Fluoro-azetidine-1-carbonyl)-2-methyl-2H-pyrazole-3-carboxylic acid (2-dimethylamino-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-amide

Procedure

Using 3-fluoro-azetidine and 5-(2-dimethylamino-[1,2,4]triazolo[1,5-a]pyridin-6-ylcarbamoyl)-1-methyl-1H-pyrazole-4-carboxylic acid, the title compound was prepared in the same manner as described for example 2. Light yellow solid (160 mg, 68%). MS: m/z=387 (M+H+).

Sources & evidence

ORD record
ord-d5794ab4225f49f88d754292ee0632da
Source dataset
uspto-grants-2015_02
Patent number
US08946427B2

Reaction notes

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