Morpholine → 2-Methyl-4-(morpholine-4-carbonyl)-2H-pyrazole-3-carboxylic acid (2-diethylamino-[1,2,4]triazolo [1,5-a]pyridin-6-yl)-amide
Reaction equation
[NH:1]1[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.[CH2:7]([N:9]([CH2:31][CH3:32])[C:10]1[N:30]=[C:13]2[CH:14]=[CH:15][C:16]([NH:18][C:19]([C:21]3[N:25]([CH3:26])[N:24]=[CH:23][C:22]=3[C:27](O)=[O:28])=[O:20])=[CH:17][N:12]2[N:11]=1)[CH3:8]>>[CH2:31]([N:9]([CH2:7][CH3:8])[C:10]1[N:30]=[C:13]2[CH:14]=[CH:15][C:16]([NH:18][C:19]([C:21]3[N:25]([CH3:26])[N:24]=[CH:23][C:22]=3[C:27]([N:1]3[CH2:6][CH2:5][O:4][CH2:3][CH2:2]3)=[O:28])=[O:20])=[CH:17][N:12]2[N:11]=1)[CH3:32]Participants
3
Procedure
Using morpholine and 5-(2-diethylamino-[1,2,4]triazolo[1,5-a]pyridin-6-ylcarbamoyl)-1-methyl-1H-pyrazole-4-carboxylic acid, the title compound was prepared in the same manner as described for example 2. White solid (65 mg, 94%). MS: m/z=357 (M+H+).
Sources & evidence
- ORD record
- ord-659b59f99b7d451a8f039c1c60862fc2
- Source dataset
- uspto-grants-2015_02
- Patent number
- US08946427B2
Reaction notes
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