2-(3-Methoxy-pyrrolidin-1-yl)-[1,2,4]triazolo[1,5-a]pyridin-6-ylamine → 5-[2-(3-Methoxy-pyrrolidin-1-yl)-[1,2,4]triazolo[1,5-a]pyridin-6-ylcarbamoyl]-1-methyl-1H-pyrazole-4-carboxylic acid ethyl ester

HRID 1844482Notes

Reaction equation

HRID 1844482 reaction equation
[CH3:1][O:2][CH:3]1[CH2:7][CH2:6][N:5]([C:8]2[N:17]=[C:11]3[CH:12]=[CH:13][C:14]([NH2:16])=[CH:15][N:10]3[N:9]=2)[CH2:4]1.[CH2:18]([O:20][C:21]([C:23]1[CH:24]=[N:25][N:26]([CH3:46])[C:27]=1[C:28](=[O:45])NC1C=CC2N(N=C(N3CCOCC3)N=2)C=1)=[O:22])[CH3:19]>>[CH2:18]([O:20][C:21]([C:23]1[CH:24]=[N:25][N:26]([CH3:46])[C:27]=1[C:28](=[O:45])[NH:16][C:14]1[CH:13]=[CH:12][C:11]2[N:10]([N:9]=[C:8]([N:5]3[CH2:6][CH2:7][CH:3]([O:2][CH3:1])[CH2:4]3)[N:17]=2)[CH:15]=1)=[O:22])[CH3:19]

Participants

3

Reactant 2

HCID 894637682-(3-Methoxy-pyrrolidin-1-yl)-[1,2,4]triazolo[1,5-a]pyridin-6-ylamineHCID 894647211-methyl-5-(2-morpholin-4-yl-[1,2,4]triazolo[1,5-a]pyridin-6-ylcarbamoyl)-1H-pyrazole-4-carboxylic acid ethyl ester

Product 1

HCID 894642715-[2-(3-Methoxy-pyrrolidin-1-yl)-[1,2,4]triazolo[1,5-a]pyridin-6-ylcarbamoyl]-1-methyl-1H-pyrazole-4-carboxylic acid ethyl ester

Procedure

Using 2-(3-Methoxy-pyrrolidin-1-yl)-[1,2,4]triazolo[1,5-a]pyridin-6-ylamine, this compound was prepared following the same method as for the synthesis of 1-methyl-5-(2-morpholin-4-yl-[1,2,4]triazolo[1,5-a]pyridin-6-ylcarbamoyl)-1H-pyrazole-4-carboxylic acid ethyl ester. Off white solid (1.2 g, 59%). MS: m/z=414 (M+H+).

Workup

  1. customthis compound was prepared

Sources & evidence

ORD record
ord-07798ef0d06342528bf3eb87cd5b05aa
Source dataset
uspto-grants-2015_02
Patent number
US08946427B2

Reaction notes

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