Morpholine → 2-Methyl-4-(morpholine-4-carbonyl)-2H-pyrazole-3-carboxylic acid [2-(3-methoxy-pyrrolidin-1-yl)-[1,2,4]triazolo[1,5-a]pyridin-6-yl]-amide

HRID 1844484Notes

Reaction equation

[NH:1]1[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.[CH3:7][O:8][CH:9]1[CH2:13][CH2:12][N:11]([C:14]2[N:34]=[C:17]3[CH:18]=[CH:19][C:20]([NH:22][C:23]([C:25]4[N:29]([CH3:30])[N:28]=[CH:27][C:26]=4[C:31](O)=[O:32])=[O:24])=[CH:21][N:16]3[N:15]=2)[CH2:10]1>>[CH3:7][O:8][CH:9]1[CH2:13][CH2:12][N:11]([C:14]2[N:34]=[C:17]3[CH:18]=[CH:19][C:20]([NH:22][C:23]([C:25]4[N:29]([CH3:30])[N:28]=[CH:27][C:26]=4[C:31]([N:1]4[CH2:6][CH2:5][O:4][CH2:3][CH2:2]4)=[O:32])=[O:24])=[CH:21][N:16]3[N:15]=2)[CH2:10]1

Participants

Reactant 2

HCID 8083Morpholine

HCID 894643825-[2-(3-Methoxy-pyrrolidin-1-yl)-[1,2,4]triazolo[1,5-a]pyridin-6-ylcarbamoyl]-1-methyl-1H-pyrazole-4-carboxylic acid

Product 1

HCID 715347492-Methyl-4-(morpholine-4-carbonyl)-2H-pyrazole-3-carboxylic acid [2-(3-methoxy-pyrrolidin-1-yl)-[1,2,4]triazolo[1,5-a]pyridin-6-yl]-amide

Procedure

Using morpholine and 5-[2-(3-Methoxy-pyrrolidin-1-yl)-[1,2,4]triazolo[1,5-a]pyridin-6-ylcarbamoyl]-1-methyl-1H-pyrazole-4-carboxylic acid, the title compound was prepared in the same manner as described for example 2. Off white solid (42 mg, 51%). MS: m/z=455 (M+H+).

Sources & evidence

ORD record: ord-e0d5563bec3c4c28950fec4e8ad4f6b9
Source dataset: uspto-grants-2015_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08946427B2

Reaction notes

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